Identification of acis-acting element involved in the regulation of BACE1 mRNA alternative splicing
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چکیده
منابع مشابه
Identification of an intronic splicing regulatory element involved in auto-regulation of alternative splicing of SCL33 pre-mRNA.
In Arabidopsis, pre-mRNAs of serine/arginine-rich (SR) proteins undergo extensive alternative splicing (AS). However, little is known about the cis-elements and trans-acting proteins involved in regulating AS. Using a splicing reporter (GFP-intron-GFP), consisting of the GFP coding sequence interrupted by an alternatively spliced intron of SCL33, we investigated whether cis-elements within this...
متن کاملIdentification of an intronic splicing regulatory element involved in autoâ•’regulation of alternative splicing of SCL33 preâ•’mRNA
Julie Thomas, Saiprasad G. Palusa, Kasavajhala V.S.K. Prasad, Gul Shad Ali, Giridara-Kumar Surabhi, Asa Ben-Hur, Salah E. Abdel-Ghany and Anireddy S.N. Reddy* Department of Biology, Program in Molecular Plant Biology, Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA, and Department of Computer Science and Program in Molecular Plant Biology, Colorado ...
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Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis because BIM activity is partly determined by the alternative splicing of exons 3 or 4, whereby exo...
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Yue, B-G. 2000. Regulation of adenovirus alternative pre-mRNA splicing. Functional characterization of exonic and intronic splicing enhancer elements. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 926. 55pp. Uppsala. ISBN 91-554-4712-0 Pre-mRNA splicing and alternative pre-mRNA splicing are key regulatory steps controlling gene exp...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2009
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2009.06026.x